If I was making an Alien vs. Predator movie I would probaly have it be on a mass Weyland Yutani ship floating in space, then a ship of Bad Bloods board the ship and kill off most of the humans, but get trapped in a chamber of the ship and are knocked out from gas so the humans could capture them and run tests. Later though while they are putting the knocked out predators in cages and removing their weapons some foolish young workers go into the predators ship and break glass containers holding the aliens, setting them free. Now grown aliens escape and facehuggers jump on the workers faces. While this is going on a predator wakes up while having his weapons remover and kills the scientist, also letting free the other predators. From then on out the humans must survive in the middle of their war and escape from the ship evan when the escape pods are on the other side of the thirty-five mile long space vessel trying not to be killed by the creatures.
In this movie for actors I might have James Franco and Jeff Bridges be in it otherwise I'm not sure who I would have in it. The movie would be set in about 2175 or something and there would not be a Queen Alien, but the Xenomorphs would start to build a hive onboard.